Hey Fertile Guides! I wanted to try something different this month. Let’s discuss an article. Read the article below and then share your thoughts. Looking forward to the discussion :)
Hmmm. I think I have more questions than answers! First, estrone levels are naturally higher postmenopause, so the fact that most of the research seems to be based on that population makes it difficult to know how to extrapolate such data to a TTC/pregnant population. I also wonder about the seeming conclusion that "elevated urinary estrone (but not other forms of estrogen) was associated with higher beta-glucuronidase activity, suggesting that recirculation of estrone may be higher than other forms of estrogen with increased beta-glucuronidase activity."; why do we believe urinary estrone levels reflect recirculation levels? Couldn't urinary levels suggest LESS is going into circulation?
I think more research is needed to know how urinary metabolites correlate to bodily levels of estrogen, what types are generally recirculated, and what healthy levels of beta-glucuronidase are in the non-postmenopausal population.
It would be interesting to see more data with a TTC or pregnant population. Would the values be similar? Would we find that all forms of estrogen are disrupted? Of course, it's hard to know without seeing the numbers. I do believe that the gut is likely a key to many cases of infertility and wonder to what degree the various microbial and fungal strains are impacting hormone elimination, recirculation, and even mimicking - thinking about yeast on that last note.
Hmmm. I think I have more questions than answers! First, estrone levels are naturally higher postmenopause, so the fact that most of the research seems to be based on that population makes it difficult to know how to extrapolate such data to a TTC/pregnant population. I also wonder about the seeming conclusion that "elevated urinary estrone (but not other forms of estrogen) was associated with higher beta-glucuronidase activity, suggesting that recirculation of estrone may be higher than other forms of estrogen with increased beta-glucuronidase activity."; why do we believe urinary estrone levels reflect recirculation levels? Couldn't urinary levels suggest LESS is going into circulation?
I think more research is needed to know how urinary metabolites correlate to bodily levels of estrogen, what types are generally recirculated, and what healthy levels of beta-glucuronidase are in the non-postmenopausal population.
It would be interesting to see more data with a TTC or pregnant population. Would the values be similar? Would we find that all forms of estrogen are disrupted? Of course, it's hard to know without seeing the numbers. I do believe that the gut is likely a key to many cases of infertility and wonder to what degree the various microbial and fungal strains are impacting hormone elimination, recirculation, and even mimicking - thinking about yeast on that last note.